期刊
CURRENT OPINION IN ORGAN TRANSPLANTATION
卷 13, 期 4, 页码 358-365出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOT.0b013e3283061149
关键词
acute rejection; microorganisms; Toll-like receptor; tolerance
资金
- NIAID NIH HHS [R01 AI064660, R01 AI052464, R03 AI069284-01A2, AI071080-01, R01 AI071080, U19 AI051728-050003, R03 AI069284, U19 AI051728, R01 AI072630-02, R01 AI072630, R01 AI052464-05, R56 AI064660, AI064660] Funding Source: Medline
- NIDDK NIH HHS [R21 DK073529, R21 DK073529-01] Funding Source: Medline
Purpose of review This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation. Recent findings During an alloresponse, Toll-like receptors can be engaged by both damage-induced endogenous ligands or microbial-associated molecular patterns. The damage-induced molecule high mobility group box 1 protein and its binding to Toll-like receptor 4 have been identified as major initiators of antitumor and antitransplant immune responses. Type I interferon signaling plays an important role in the pro-rejection effect mediated by Toll-like receptor agonists and some bacteria. Similar pathways, however, in neonates can result in inhibition rather than activation of alloimmune responses. Summary The consequences of Toll-like receptor engagement by endogenous and exogenous ligands in transplantation may depend on the relative induction of inflammatory and regulatory pathways and the stage of development of the immune system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据