期刊
CURRENT OPINION IN ONCOLOGY
卷 25, 期 1, 页码 66-75出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCO.0b013e32835b7c81
关键词
biomarker; cancer; exosomes; metabolism; metastasis; microvesicles
类别
资金
- Sao Paulo State Foundation (FAPESP)
- National Institute for Oncogenomics (INCITO) MCT/CNPq/FAPESP
Purpose of review Exosomes and microvesicles are secreted particles of 30-200 nm in diameter, delimited by a lipid bilayer and containing a wide range of membrane-bound or free proteins and nucleic acids (in particular mRNA and miRNA). Here, we review the properties of tumor-cell-derived microvesicles as carriers of molecular information in relation to cancer progression and promotion of metastasis. Recent findings Microvesicles from tumor cells operate as signaling platforms that diffuse in the extracellular space to target cells in the microenvironment, modulating the interactions of tumor cells with stromal, inflammatory, dendritic, immune or vascular cells and priming the formation of the metastatic niche. Summary Because of their stability, exosomes and microvesicles can be retrieved in bodily fluids as biomarkers for cancer detection and monitoring. They offer a range of molecular targets for controlling cell-cell interactions during invasion and metastasis.
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