期刊
CURRENT OPINION IN ONCOLOGY
卷 22, 期 4, 页码 307-311出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCO.0b013e32833aa9de
关键词
erythropoietin; erythropoietin receptors; tumour progression; venous thromboembolism
类别
Purpose of review Anaemia is a frequent complication of cancer. Recently, some concerns have appeared regarding the safety of erythropoiesis-stimulating agents (ESAs) for the treatment of anaemia in cancer patients. The current review will analyse the main arguments in favour of erythropoietin (EPO), as well as those against EPO in chemotherapy-induced anaemia and in cancer-related anaemia. The principal concerns are tumour progression, increased mortality and the risk of venous thromboembolic events (VTEs). Recent meta-analyses have come to divergent conclusions. Recent findings Several meta-analyses have reviewed the data regarding VTEs, EPO receptors on tumours and tumour progression as well as mortality. Summary As of now, ESAs should only be used within the indications as given in the various guidelines.
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