期刊
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
卷 22, 期 3, 页码 235-241出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GCO.0b013e328338c152
关键词
bone marrow; endometriosis; endometrium; oocyte; reproduction; stem cells
资金
- NICHD NIH HHS [R01 HD036887, U54 HD052668, U54 HD052668-05, R01 HD036887-10] Funding Source: Medline
Purpose of review To review the latest developments in reproductive tract stem cell biology. Recent findings In 2004, two studies indicated that ovaries contain stem cells which form oocytes in adults and that can be cultured in vitro into mature oocytes. A live birth after orthotopic transplantation of cyropreserved ovarian tissue in a woman whose ovaries were damaged by chemotherapy demonstrates the clinical potential of these cells. In the same year, another study provided novel evidence of endometrial regeneration by stem cells in women who received bone marrow transplants. This finding has potential for the use in treatment of uterine disorders. It also supports a new theory for the cause of endometriosis, which may have its origin in ectopic transdifferentiation of stem cells. Several recent studies have demonstrated that fetal cells enter the maternal circulation and generate microchimerism in the mother. The uterus is a dynamic organ permeable to fetal stem cells, capable of transdifferentiation and an end organ in which bone marrow stem cells may differentiate. Finally stem cell transformation can be an underlying cause of ovarian cancer. Summary Whereas we are just beginning to understand stem cells, the potential implications of stem cells to reproductive biology and medicine are apparent.
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