期刊
CURRENT OPINION IN NEUROLOGY
卷 27, 期 3, 页码 361-368出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WCO.0000000000000087
关键词
autoimmune encephalitis; herpes simplex encephalitis; immunotherapy; neuronal surface antibodies; viral encephalitis
资金
- Instituto Carlos III [FI12/00366]
- FIS [PI11/01780]
- National Institutes of Health [RO1NS077851, MH094741]
- Fundacio la Marato TV3 [101530]
- National Institutes of Health
- McKnight Neuroscience of Brain Disorders award
- Fondo de Investigaciones Sanitarias
- Fundacio la Marato de TV3
- ICREA Funding Source: Custom
Purpose of reviewThis review describes the main types of autoimmune encephalitis with special emphasis on those associated with antibodies against neuronal cell surface or synaptic proteins, and the differential diagnosis with infectious encephalitis.Recent findingsThere is a continuous expansion of the number of cell surface or synaptic proteins that are targets of autoimmunity. The most recently identified include the metabotropic glutamate receptor 5 (mGluR5), dipeptidyl-peptidase-like protein-6 (DPPX), and -aminobutyric acid-A receptor (GABA(A)R). In these and previously known types of autoimmune encephalitis [N-methyl-d-aspartate receptor (NMDAR), -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), -aminobutyric acid-B receptor (GABA(B)R), leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein-like 2 (CASPR2)], the prodromal symptoms or types of presentations often suggest a viral encephalitis. We review here clues that help in the differential diagnosis with infectious encephalitis. Moreover, recent investigations indicate that viral encephalitis (e.g., herpes simplex) can trigger synaptic autoimmunity. In all these disorders, immunotherapy is usually effective.SummaryAutoimmune encephalitis comprises an expanding group of potentially treatable disorders that should be included in the differential diagnosis of any type of encephalitis.Video Abstracthttp://links.lww.com/CONR/A25
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据