期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 36, 页码 12346-12354出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0696-15.2015
关键词
head-direction cell; juxtacellular recordings; layer 3; medial entorhinal cortex; spatial navigation
资金
- Werner Reichardt Centre for Integrative Neuroscience (CIN) at the Eberhard Karls University of Tubingen - Deutsche Forschungsgemeinschaft [EXC 307]
- Humboldt-Universitat zu Berlin
- Bernstein Center for Computational Neuroscience Berlin (German Federal Ministry of Education and Research, Forderkennzeichen) [01GQ1001A]
- Neuro-Cure, a Neuro-Behavior European Research Council grant
- Gottfried Wilhelm Leibniz Prize of the Deutsche Forschungsgemeinschaft
Layer 3 of the medial entorhinal cortex is a major gateway from the neocortex to the hippocampus. Here we addressed structure-function relationships in medial entorhinal cortex layer 3 by combining anatomical analysis with juxtacellular identification of single neurons in freely behaving rats. Anatomically, layer 3 appears as a relatively homogeneous cell sheet. Dual-retrograde neuronal tracing experiments indicate a large overlap between layer 3 pyramidal populations, which project to ipsilateral hippocampus, and the contralateral medial entorhinal cortex. These cells were intermingled within layer 3, and had similar morphological and intrinsic electrophysiological properties. Dendritic trees of layer 3 neurons largely avoided the calbindin-positive patches in layer 2. Identification of layer 3 neurons during spatial exploration (n = 17) and extracellular recordings (n = 52) pointed to homogeneous spatial discharge patterns. Layer 3 neurons showed only weak spiking theta rhythmicity and sparse head-direction selectivity. A majority of cells (50 of 69) showed no significant spatial modulation. All of the similar to 28% of neurons that carried significant amounts of spatial information (19 of 69) discharged in irregular spatial patterns. Thus, layer 3 spatiotemporal firing properties are remarkably different from those of layer 2, where theta rhythmicity is prominent and spatially modulated cells often discharge in grid or border patterns.
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