期刊
CURRENT OPINION IN NEUROLOGY
卷 21, 期 5, 页码 519-526出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WCO.0b013e32830f1e3b
关键词
chronic inflammatory demyelinating polyradiculoneuropathy; clinimetrics; Guillain-Barre syndrome; polyneuropathy; randomized controlled trial
Purpose of review New randomized controlled trials are very much needed to improve the outcome in patients with a variety of peripheral neuropathies. A relatively low incidence of immunemediated neuropathies such as Guillain-Barre syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy, and slow progression in diabetic or hereditary neuropathies may hinder a rapid inclusion and may lead to undesirable extended trial duration. Recent findings Some recent randomized controlled trials use modern trial methodology. Identification of prognostic factors, stratification for important variables at randomization, and the selection of appropriate outcome measurements using a modern clinimetric approach may contribute to a more proper randomized controlled trial design for trials that can be conducted within a limited time frame. Summary Modern trial methodology and the appropriate use of outcome measurements may improve the quality and reduce the numbers of patients needed in randomized controlled trials in patients with peripheral neuropathies.
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