期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 26, 期 -, 页码 88-95出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2013.12.013
关键词
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资金
- National Institute of Health [NS34994, MH54671, NS074015]
- Human Frontier Science Program
- J.D. McDonnell Foundation
- Bettencourt Schueller Foundation
- NCATS [UL1 TR000038]
Identification and manipulation of different GABAergic interneuron classes in the behaving animal are important to understand their role in circuit dynamics and behavior. The combination of optogenetics and large-scale neuronal recordings allows specific interneuron populations to be identified and perturbed for circuit analysis in intact animals. A crucial aspect of this approach is coupling electrophysiological recording with spatially and temporally precise light delivery. Focal multisite illumination of neuronal activators and silencers in predetermined temporal configurations or a closed loop manner opens the door to addressing many novel questions. Recent progress demonstrates the utility and power of this novel technique for interneuron research.
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