期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 23, 期 5, 页码 760-766出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2013.04.007
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Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of narcolepsy; the contribution of each orexin receptor subtype to the narcoleptic phenotypes; and the etiology of orexin neuronal death. It also raises the possibility of novel therapies targeting the orexin system for sleep disorders including insomia and narcolepsy-cataplexy.
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