期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 23, 期 5, 页码 854-863出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2013.02.008
关键词
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资金
- National Space Biomedical Research Institute through NASA NCC [9-58]
- NIH [HL102119, NR004281]
- ONR [N00014-11-1-0361]
Lifestyles involving sleep deprivation are common, despite mounting evidence that both acute total sleep deprivation and chronically restricted sleep degrade neurobehavioral functions associated with arousal, attention, memory and state stability. Current research suggests dynamic differences in the way the central nervous system responds to acute versus chronic sleep restriction, which is reflected in new models of sleep wake regulation. Chronic sleep restriction likely induces long-term neuromodulatory changes in brain physiology that could explain why recovery from it may require more time than from acute sleep loss. High intraclass correlations in neurobehavioral responses to sleep loss suggest that these trait-like differences are phenotypic and may include genetic components. Sleep deprivation induces changes in brain metabolism and neural activation that involve distributed networks and connectivity.
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