期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 22, 期 3, 页码 383-388出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.09.002
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资金
- RIKEN
- NIH grant [R01 DA17310]
- MEXT, Japan
- 'Beatriu de Pinos' fellowship from the 'Generalitat de Catalunya'
- Grants-in-Aid for Scientific Research [20240032, 23650172, 22110006] Funding Source: KAKEN
Dendritic spines are small mushroom-like protrusions arising from neurons where most excitatory synapses reside. Their peculiar shape suggests that spines can serve as an autonomous postsynaptic compartment that isolates chemical and electrical signaling. How neuronal activity modifies the morphology of the spine and how these modifications affect synaptic transmission and plasticity are intriguing issues. Indeed, the induction of long-term potentiation (LTP) or depression (LTD) is associated with the enlargement or shrinkage of the spine, respectively. This structural plasticity is mainly controlled by actin filaments, the principal cytoskeletal component of the spine. Here we review the pioneering microscopic studies examining the structural plasticity of spines and propose how changes in actin treadmilling might regulate spine morphology.
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