期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 22, 期 5, 页码 844-849出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2012.04.012
关键词
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资金
- NIH [R01-CA136495]
- Department of Defense (DoD) Peer Reviewed Cancer Research Program (PRCRP) [CA100469]
- W.M. Keck Foundation
- Pew Charitable Trusts
- CDMRP [CA100469, 545619] Funding Source: Federal RePORTER
Brain tumors are devastating owing to the high fatality rate and the devastating impact on life qualities of patients. Recent advancement of comparative transcriptome profiling tools and mouse genetic models has greatly deepened our understanding of the developmental origins of these tumors, which could lead to effective therapeutic strategies. We review recent progresses in three types of brain tumors: ependymoma, medulloblastoma, and malignant glioma. The conceptual framework established by these studies converged on three important aspects. First, subtypes in each tumor group originate from distinct cell types. Second, each cell-of-origin is uniquely susceptible to some but not other genetic mutations. Lastly, mutant stem cells may not transform until they differentiate into more restricted progenitor cell type. Overall, these findings indicate the existence of intricate interactions between gene mutations and developmental program for the formation of brain tumors.
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