期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 22, 期 3, 页码 559-563出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.09.001
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资金
- NIA NIH HHS [R01 AG032132-18, R01 AG032132] Funding Source: Medline
- NIMH NIH HHS [R37 MH049159, R01 MH049159, R01 MH049159-23, R01 MH091119, R01 MH091119-01A1] Funding Source: Medline
- NINDS NIH HHS [R01 NS032827] Funding Source: Medline
Since the initial findings that NMDA receptors play important roles in cellular models of learning as well as neurotoxicity, abnormal function of this receptor has been considered a potential mechanism in the pathophysiology underlying Alzheimer's disease. Treatment of Alzheimer's disease with an NMDA receptor antagonist began several years ago, with some limited success. More recent mechanistic studies have examined the role of NMDA receptors in the synaptic effects of beta amyloid (A beta).
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