期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 21, 期 4, 页码 602-608出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.05.031
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资金
- National Science Foundation [IOS-1025849]
- Kavli Institute for Brain Science
- Alfred P. Sloan Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1025849] Funding Source: National Science Foundation
This review focuses on recent progress in understanding mechanisms for filtering self-generated sensory signals in cerebellum-like circuits in fish and mammals. Recent in vitro studies in weakly electric gymnotid fish have explored the interplay among anti-Hebbian plasticity, synaptic dynamics, and feedforward inhibition in canceling self-generated electrosensory inputs. Studies of the mammalian dorsal cochlear nucleus have revealed multimodal integration and anti-Hebbian plasticity, suggesting that this circuit may adaptively filter incoming auditory information. In vivo studies in weakly electric mormryid fish suggest a key role for granule cell coding in sensory filtering. The clear links between synaptic plasticity and systems level sensory filtering in cerebellum-like circuits may provide insights into hypothesized adaptive filtering functions of the cerebellum itself.
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