期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 21, 期 6, 页码 866-872出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.05.013
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资金
- NIMH NIH HHS [R01 MH051234-16, P50 MH084053-05, R01 MH043784, R21 MH085108-02, R21 MH085108, R01 MH051234, R01 MH071533, P50 MH084053] Funding Source: Medline
Deficits of cognitive control in schizophrenia are associated with altered gamma oscillations in the prefrontal cortex. Paralbumin basket interneurons, which innervate the perisomatic region of pyramidal neurons, appear to play a key role in generating cortical gamma oscillations. In the prefrontal cortex of subjects with schizophrenia, alterations are present in both pre- and post-synaptic markers of the strength of GABA inputs from parvalbumin basket neurons to pyramidal neurons. These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia.
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