期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 20, 期 5, 页码 610-616出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2010.07.003
关键词
-
资金
- Deutsche Forschungsgemeinschaft [SFB 807, SFB 487]
- Bernstein Center Gottingen
- Cluster of Excellence Frankfurt Macromolecular Complexes
- Max-Planck-Society
The discovery of the light-gated cation channel Channelrhodopsin-2 (ChR2) and the use of the rediscovered light-driven Cl-pump halorhodopsin (HR) as optogenetic tools genetically encoded switches that enable neurons to be turned on or off with bursts of light refines the functional study of neurons in larger networks. Cell-specific expression allows a fast optical scanning approach to determine neuronal crosstalk following plasticity at the single synapse level or long-range projections in locomotion and somatosensory networks. Both rhodopsins proved to work functionally and could evoke behavioral responses in lower model organisms, reinstall rudimentary visual perception in blind mice and were set in a biomedical context with the investigation of neurodegenerative diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据