期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 2, 页码 550-558出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2557-14.2015
关键词
multiple sclerosis; connectivity; neuroplasticity; radiologically isolated syndrome; resting state networks
资金
- Biogen Idec
- Merck Serono
- Bayer Schering Pharma
- Teva Pharmaceutical Industries
- Novartis
- Sanofi Aventis
- BioMS Medical
- NeuroRx Research
- Italian Multiple Sclerosis Society
Wehypothesized that appraisal of brain connectivity may shed light on the substrate of the radiologically isolated syndrome (RIS), a term applied to asymptomatic subjects with brain MRI abnormalities highly suggestive of multiple sclerosis. We thus used a multimodal MRI approach on the human brain by modeling measures of microstructural integrity of white matter (WM) tracts with those of functional connectivity (FC) at the level of resting state networks in RIS subjects, demographically matched normal controls (NC), and relapsing-remitting (RR) MS patients, also matched with RIS for brain macrostructural damage (i.e., lesions and atrophy). Compared with NC, in both RIS subjects and MS patients altered integrity of WM tracts was present. However, RIS subjects showed, at a less conservative threshold, lower diffusivities than RRMS patients in distinct cerebral associative, commissural, projection, and cerebellar WM tracts, suggesting a relatively better anatomical connectivity. FC was similar in NC and RIS subjects, even in the presence of important risk factors for MS(spinal cord lesions, oligoclonal bands, and dissemination in time on MRI) and increased in RRMS patients in two clinically relevant networks subserving processing (sensorimotor) and control (working memory) functions. In RIS, the lack of functional reorganization in key brain networks may represent a model of functional reserve,which may become upregulated, with an adaptive or maladaptive role, only at a later stage in case of occurrence of clinical deficit.
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