期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 19, 期 2, 页码 168-173出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2009.05.012
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资金
- National Institute on Deafness and Other Communication Disorders [DC-008885]
Brain circuits undergo distributed rearrangements throughout life: development, experience and behavior constantly modify synaptic strength and network connectivity. Despite these changes, neurons and circuits need to preserve their functional stability. Single neurons maintain their spontaneous firing rate within functional working ranges by regulating the efficacy of their synaptic inputs. But how do networks maintain a stable behavior? Is network homeostasis a consequence of cell autonomous mechanisms? In this article we will review recent evidence showing that network homeostasis is more than the sum of single-neuron homeostasis and that high-order network stability can be achieved by coordinated inter-cellular interactions.
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