期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 18, 期 3, 页码 292-296出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2008.07.001
关键词
-
资金
- EU-FP6 [LSHG-CP-2006-037900]
- Temasek Life Sciences Laboratory
microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse cellular and developmental processes. Many miRNAs are expressed specifically in the central nervous system, where they have roles in differentiation, neuronal survival, and potentially also in plasticity and learning. The absence of miRNAs in a variety of specific postmitotic neurons can lead to progressive loss of these neurons and behavioral defects reminiscent of the phenotypes seen in the pathologies of neurodegenerative diseases. Here, we review recent studies which provide a link between miRNA function and neurodegeneration. We also discuss evidence which might suggest involvement of miRNAs in the emergence or progression of neurodegenerative diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据