期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 18, 期 3, 页码 307-313出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2008.08.008
关键词
-
资金
- National Institutes of Health [NS044916]
- Dr Miriam and Sheldon G. Adelson Medical Research Foundation
- National Multiple Selerosis Society
Action potential initiation, modulation, and duration in neurons depend on a variety of Na+ and K+ channels that are highly enriched at the axon initial segment (AIS). The AIS also has high densities of cell adhesion molecules (CAMs), modulatory proteins, and a unique extracellular matrix (ECM). In contrast to other functional domains of axons (e.g. the nodes of Ranvier and axon terminals) whose development depends on the interactions with different cells (e.g. myelinating glia and postsynaptic cells), the recruitment and retention of AIS proteins is intrinsically specified through axonal cytoskeletal and scaffolding proteins. We speculate that the AIS has previously unappreciated forms of plasticity that influence neuronal excitability, and that AIS plasticity is regulated by the developmental or activity-dependent modulation of scaffolding protein levels rather than directly altering ion channel expression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据