期刊
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
卷 23, 期 2, 页码 106-112出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.mnh.0000441047.13912.56
关键词
sodium transport; angiotensin II; angiotensin-converting enzyme; kidney; blood pressure
资金
- NIH [R00DK083455, R01HL110353]
- AHA [13BGIA14680069]
- NHLBI
- NIDDK
- AHA
Purpose of review This review presents novel findings regarding the renal angiotensin-converting enzyme (ACE) and its role in blood pressure (BP) control. Recent findings The textbook flow diagram of the renin-angiotensin system (RAS) shows the pulmonary endothelium as the main source of the ACE that converts angiotensin I to angiotensin II. However, ACE is made in large quantities by the kidneys, which raises the important question of what precisely is the function of renal ACE? Recent studies in gene-targeted mice indicates that renal ACE plays a dominant role in regulating the response of the kidney to experimental hypertension. In particular, renal ACE and locally generated angiotensin II affect the activity of several key sodium transporters and the induction of sodium and water retention resulting in the elevation of BP. New experimental data link the renal ACE/angiotensin II pathway and the local regulation of sodium transport as key elements in the development of hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据