期刊
CURRENT OPINION IN MICROBIOLOGY
卷 17, 期 -, 页码 82-90出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2013.12.001
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资金
- Searle Scholars Program
- Rita Allen Scholars Program
- Irma T Hirschl Award
- Sinsheimer Foundation
- NIH Director's New Innovator Award [1DP2AI104556-01]
CRISPR-Cas systems protect prokaryotes from viruses and plasmids and function primarily as an adaptive immune system in these organisms. Recent discoveries, howeVer, revealed unexpected roles for CRISPR loci as barriers to horizontal gene transfer and as modulators of gene expression. We review how both of these functions of CRISPR-Cas systems can affect the emergence and virulence of human bacterial pathogens.
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