期刊
CURRENT OPINION IN MICROBIOLOGY
卷 22, 期 -, 页码 73-78出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2014.09.012
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- NHLBI NIH HHS [R01 HL059842] Funding Source: Medline
- NIAID NIH HHS [R01 AI033774, R01 AI052733] Funding Source: Medline
Extracellular vesicles (EV) produced by eukaryotic microbes play an important role during infection. EV release is thought to benefit microbial invasion by delivering a high concentration of virulence factors to distal host cells or to the cytoplasm of a host cell. EV can significantly impact the outcome of host pathogen interaction in a cargo-dependent manner. Release of EV from eukaryotic microbes poses unique challenges when compared to their bacterial or archaeal counterparts. Firstly, the membrane-bound organelles within eukaryotes facilitate multiple mechanisms of vesicle generation. Secondly, the fungal cell wall poses a unique barrier between the vesicle release site at the plasma membrane and its destined extracellular environment. This review focuses on these eukaryotic-specific aspects of vesicle synthesis and release.
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