期刊
CURRENT OPINION IN MICROBIOLOGY
卷 21, 期 -, 页码 45-50出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2014.09.002
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资金
- Canada Research Chair
- Canadian Institutes for Health Research (CIHR)
- Natural Sciences and Engineering Research Council
- CIHR Fellowship
- Canada Research Chair
- Canadian Institutes for Health Research (CIHR)
- Natural Sciences and Engineering Research Council
- CIHR Fellowship
The antibiotic resistome is dynamic and ever expanding, yet its foundations were laid long before the introduction of antibiotics into clinical practice. Here, we revisit our theoretical framework for the resistome concept and consider the many factors that influence the evolution of novel resistance genes, the spread of mobile resistance elements, and the ramifications of these processes for clinical practice. Observing the trends and prevalence of genes within the antibiotic resistome is key to maintaining the efficacy of antibiotics in the clinic.
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