期刊
CURRENT OPINION IN MICROBIOLOGY
卷 16, 期 2, 页码 184-191出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2012.12.004
关键词
-
类别
资金
- Imperial College London
- Medical Research Council
- Wellcome Trust and Biotechnology
- Biological Sciences Research Council (UK)
Intracellular growth of bacterial pathogens is usually measured at the whole population level, which masks potential cell-to-cell variation. More direct measurements of replication using microscopy and Flow Cytometry have revealed extensive heterogeneity among populations of intracellular bacteria. Heterogeneity could result from differential exposure to nutritional deprivation and host cell antimicrobial activities, as well as variability in production or efficacy of virulence molecules. Furthermore, bacteria have evolved specific mechanisms to generate epigenetic variation. These include unequal partitioning of proteins during cell division, genetic phase variation and activation of toxin/antitoxin systems. An important aspect of heterogeneity concerns the generation of viable, non-replicating bacteria. These are predicted to confer tolerance to host-induced stress and antibiotics, and to be sources of persistent infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据