期刊
CURRENT OPINION IN MICROBIOLOGY
卷 16, 期 3, 页码 339-348出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2013.03.010
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资金
- Medical Research Council [U105170648]
- National Association for Colitis and Crohn's Disease [M/11/3]
- MRC [MC_U105170648] Funding Source: UKRI
- Medical Research Council [MC_U105170648] Funding Source: researchfish
Selective autophagy is an important effector mechanism of cell autonomous immunity, in particular against invasive bacterial species. Anti-bacterial autophagy is activated by rupture of bacteria-containing vacuoles and exposure of bacteria to the cytosol. The autophagy cargo receptors p62, NDP52 and Optineurin detect incoming bacteria that have become associated with specific 'eat-me' signals such as Galectin-8 and poly-ubiquitin and feed them into the autophagy pathway via interactions with phagophore-associated ATG8-like proteins. Here we review recent progress in the field regarding the origin of bacteria-associated 'eat-me' signals, the specific roles of individual cargo receptors and how disrupting cargo receptor function may be important for bacterial evasion of autophagy.
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