期刊
CURRENT OPINION IN MICROBIOLOGY
卷 15, 期 3, 页码 317-324出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2012.05.009
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资金
- Region V Great Lakes Regional Center of Excellence [1-U54-AI-057153]
- National Institutes of Health Regional Center of Excellence for Bio-defense and Emerging Infectious Diseases Research Program
The clostridial neurotoxins (CNTs) are the most toxic proteins for humans and include botulinum neurotoxins (BoNT) and tetanus neurotoxin (TeNT). CNT neurotropism is based upon the preferred binding and entry into neurons and specific cleavage of neuronal SNARE proteins. While chemically inactive TeNT toxoid remains an effect vaccine, the current pentavalent vaccine against botulism is in limited supply. Recent advances have facilitated the development of the next generation of BoNT vaccines, utilizing non-catalytic full-length BoNT or a subunit vaccine composed of the receptor binding domain of BoNT as immunogens. This review describes the issues and progress towards the production of a vaccine against botulism that will be effective against natural BoNT variants.
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