期刊
CURRENT OPINION IN MICROBIOLOGY
卷 15, 期 1, 页码 78-84出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2011.10.007
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资金
- US National Institutes of Health [R01 A135678, R01 DK077159, R01 A150021, R37 DK50814, R21 A1056101]
Mast cells (MCs) have been implicated in orchestrating the host's early innate immune and adaptive immune responses in several models of acute bacterial infections. Most of this activity results in early clearance of the bacteria and timely resolution of infection. However, during chronic infections because of the prolonged nature of MC-bacterial interactions, the role of the MC in determining the fate of infection is markedly more complex. Depending on the nature of the pathogen, severity of infection, and its association with a preexisting inflammatory disease, MCs may promote rather than contain chronic infections and exacerbate their pathological sequellae.
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