期刊
CURRENT OPINION IN MICROBIOLOGY
卷 14, 期 2, 页码 205-211出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2011.01.002
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资金
- StoMP network
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- BBSRC [BB/F003692/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/C502849/1, BB/F003692/1] Funding Source: researchfish
Phase variation yields phenotypic heterogeneity in a clonal population as the result of one of a limited number of known molecular mechanisms. These include slipped strand mispairing, site-specific recombination and epigenetic regulation mediated by DNA methylation. Recently new regulatory variants utilizing these mechanisms have been identified, which is facilitating the identification of additional phase variation events solely from genome sequence analysis. Furthermore, it is becoming increasingly clear that in many cases phase variation control is integrated with regulatory networks and with cellular processes of a growing cell. This review focuses specifically on these recent advances in the understanding of the regulation of phase variation.
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