期刊
CURRENT OPINION IN MICROBIOLOGY
卷 14, 期 5, 页码 519-523出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2011.08.003
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资金
- NIH [DP2 OD007290]
- W.M. Keck Foundation
- Program for Breakthrough Biomedical Research
New drug development strategies are needed to combat antimicrobial resistance. The object of this perspective is to highlight one such strategy: treating infections with sets of drugs rather than individual drugs. We will highlight three categories of combination therapy: those that inhibit targets in different pathways; those that inhibit distinct nodes in the same pathway; and those that inhibit the very same target in different ways. We will then consider examples of naturally occurring combination therapies produced by micro-organisms, and conclude by discussing key opportunities and challenges for making more widespread use of drug combinations.
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