期刊
CURRENT OPINION IN MICROBIOLOGY
卷 14, 期 4, 页码 400-405出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2011.06.002
关键词
-
类别
资金
- Austrian Science Foundation [FWF P-21643-B11, I-282-B09]
- Austrian Science Fund (FWF) [P 21643] Funding Source: researchfish
The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial role of iron in pathophysiology, genetic inactivation of either HapX or the siderophore system attenuates virulence of A. fumigatus in a murine model of aspergillosis. The differences in iron handling between mammals and fungi might serve to improve therapy and diagnosis of fungal infections.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据