期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 15, 页码 5935-5940出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3876-14.2015
关键词
neural coding; trigeminal ganglion; vibrissa; whisker
资金
- Biotechnology and Biological Sciences Research Council [BB/G020094/1, BB/L007282/1]
- Medical Research Council [MR/L01064X/1]
- Wellcome Trust [097820/Z/11/B]
- Spanish Ministry of Science and Innovation [BFU2011-23049]
- European Regional Development Fund
- Lord Alliance Foundation
- BBSRC [BB/G020094/1, BB/L007282/1] Funding Source: UKRI
- MRC [MR/L01064X/1] Funding Source: UKRI
Communication in the nervous system occurs by spikes: the timing precision with which spikes are fired is a fundamental limit on neural information processing. In sensory systems, spike-timing precision is constrained by first-order neurons. We found that spike-timing precision of trigeminal primary afferents in rats and mice is limited both by stimulus speed and by electrophysiological sampling rate. High-speed video of behaving mice revealed whisker velocities of at least 17,000 degrees/s, so we delivered an ultrafast ping (>50,000 degrees/s) to single whiskers and sampled primary afferent activity at 500 kHz. Median spike jitter was 17.4 mu s; 29% of neurons had spike jitter <10 mu s. These results indicate that the input stage of the trigeminal pathway has extraordinary spike-timing precision and very high potential information capacity. This timing precision ranks among the highest in biology.
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