期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 29, 页码 10523-10534出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3375-14.2015
关键词
corticogeniculate; frequency dependent depression; optogenetics; retinogeniculate; tectogeniculate; ultrastructure
资金
- National Institutes of Health [EY012716, EY022871, EY016155, EY021016, GM103507]
The dorsal lateral geniculate nucleus (dLGN) is a model system for understanding thalamic organization and the classification of inputs as drivers or modulators. Retinogeniculate terminals provide the primary excitatory drive for the relay of information to visual cortex (V1), while nonretinal inputs act in concert to modulate the gain of retinogeniculate signal transmission. How do inputs from the superior colliculus, a visuomotor structure, fit into this schema? Using a variety of anatomical, optogenetic, and in vitro physiological techniques in mice, we show that dLGN inputs from the superior colliculus (tectogeniculate) possess many of the ultrastructural and synaptic properties that define drivers. Tectogeniculate and retinogeniculate terminals converge to innervate one class of dLGN neurons within the dorsolateral shell, the primary terminal domain of direction-selective retinal ganglion cells. These dLGN neurons project to layer I of V1 to form synaptic contacts with dendrites of deeper-layer neurons. We suggest that tectogeniculate inputs act as backseat drivers, which may alert shell neurons to movement commands generated by the superior colliculus.
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