期刊
CURRENT OPINION IN MICROBIOLOGY
卷 12, 期 4, 页码 453-459出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2009.06.004
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资金
- BayGene (Bayerisches Staatsministerium for Wissenschaft, Forschung und Kunst)
- DFG [SFB 576 JH, BA 1165/5-1 SB/JH]
- BMBF
- MRC [G050145]
- Scottish Funding Council (ICHAIR)
- Medical Research Council [G0501453] Funding Source: researchfish
- MRC [G0501453] Funding Source: UKRI
Genome-scale screens for intraviral and virus-host protein interactions and the analysis of literature-curated datasets are able to provide a novel, comprehensive perspective of viruses, and virus-infected cells. Until now, large-scale interaction screens were predominantly performed with the yeast-two-hybrid (Y2H) system; however, alternative high-throughput technologies detecting binary protein interactions or protein complexes have been developed. Although many of the previous studies suffer from a rather poor validation of the results and few biological implications, these technologies potentially lead to a plethora of novel hypotheses. Here, we will give an overview of current approaches and their technical limitations, present recent examples and novel developments.
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