4.6 Review

System-level analysis of Salmonella metabolism during infection

期刊

CURRENT OPINION IN MICROBIOLOGY
卷 12, 期 5, 页码 559-567

出版社

CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2009.08.004

关键词

-

资金

  1. Deutsche Forschungsgemeinsuhaft
  2. Schweizerischer Nationalfonds

向作者/读者索取更多资源

Infectious diseases represent a major threat to human health. To develop urgently needed new control strategies, a transition from research focusing on individual factors to a more integrated system-level analysis might be needed. Such an approach faces great challenges and might require development of new concepts in large-scale data analysis. Here, I discuss for the well-characterized model pathogen Salmonella, how extensively studied metabolism can be used as a training field for infection biology at the systems level. Extensive experimental data can be analyzed in context using metabolic network visualization tools and in silico modeling based on genome-scale metabolic reconstructions. Suitable approaches to obtain still missing comprehensive quantitative data on Salmonella nutrition in infected host tissues are described. Such an integrated investigation of Salmonella metabolism during infection will enable an unprecedented large-scale understanding of pathogen in vivo activities, help to evaluate concepts and strategies for system-level analysis of host/pathogen interactions in general, and provide a basis for rational development of novel antimicrobials and efficacious live vaccines.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据