期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 20, 页码 7866-7877出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0454-15.2015
关键词
choice; decision; locus coeruleus; motivation; pupil; substantia nigra
资金
- European Research Council (ERC-BioMotiv)
- Ecole Doctorale Frontieres du Vivant
Motivation determines multiple aspects of behavior, including action selection and energization of behavior. Several components of the underlying neural systems have been examined closely, but the specific role of the different neuromodulatory systems in motivation remains unclear. Here, we compare directly the activity of dopaminergic neurons from the substantia nigra pars compacta and noradrenergic neurons from the locus coeruleus in monkeys performing a task manipulating the reward/effort trade-off. Consistent with previous reports, dopaminergic neurons encoded the expected reward, but we found that they also anticipated the upcoming effort cost in connection with its negative influence on action selection. Conversely, the firing of noradrenergic neurons increased with both pupil dilation and effort production in relation to the energization of behavior. Therefore, this work underlines the contribution of dopamine to effort-based decision making and uncovers a specific role of noradrenaline in energizing behavior to face challenges.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据