期刊
CURRENT OPINION IN MICROBIOLOGY
卷 11, 期 2, 页码 153-160出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2008.02.013
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资金
- NCI NIH HHS [R01 CA114107-03, R01 CA114107] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA114107] Funding Source: NIH RePORTER
The yeast Saccharomyces cerevisiae senses and responds to nutrients by adapting its growth rate and undergoing morphogenic transitions to ensure survival. The Tor pathway is a major integrator of nutrient-derived signals that in coordination with other signaling pathways orchestrates cell growth. Recent advances have identified novel Tor kinase substrates and established the protein trafficking membranous network and the nucleus as platforms for Tor signaling. These and other recent findings delineate distinct signaling branches emanating from membrane-associated Tor complexes to control cell growth.
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