期刊
CURRENT OPINION IN LIPIDOLOGY
卷 20, 期 3, 页码 159-164出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e32832ac180
关键词
beta-cell; ABCA1; cholesterol homeostasis; insulin; lipoproteins
资金
- National Health and Medical Research Council of Australia [482800]
Purpose of review It has recently been recognized that cholesterol homeostasis is fundamentally important for appropriate insulin secretory function of beta-cells in the pancreas. This review summarizes recent advances in understanding the relationship between p-cell cholesterol metabolism and beta-cell function. Recent findings The accumulation of cholesterol in beta-cells causes perturbations in glucose metabolism, reduces insulin secretion and can be associated with a diabetic phenotype. Cholesterol is also a key determinant of beta-cell membrane organization and cell survival. The ATP-binding cassette transporter A1, which effluxes cholesterol to lipid-free/lipid-poor apolipoprotein A-1, the principal apolipoprotein in HDLs, is crucial for maintaining beta-cell cholesterol homeorstasis and function. There is also evidence suggesting that different lipoprotein classes have varying effects on beta-cell function and survival. Summary Cholesterol is important for beta-cell function and survival. It can cause beta-cell loss if allowed to accumulate in the cells in an unregulated manner. The maintenance of beta-cell cholesterol homeostasis, therefore, is important for preventing beta-cell dysfunction, the onset of insulin resistance and the development of type 2 diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据