期刊
CURRENT OPINION IN LIPIDOLOGY
卷 19, 期 4, 页码 349-354出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e328304b681
关键词
apolipoprotein A-V; cardiovascular disease; diet; gene-environment interaction; pharmacogenomics; plasma lipids
资金
- NHLBI NIH HHS [HL 54776, U01 HL 072524-04, U01 HL072524, R01 HL054776] Funding Source: Medline
- NIA NIH HHS [5 P01 AG 023394-02, P01 AG023394] Funding Source: Medline
- NIDDK NIH HHS [DK 075030, R01 DK075030] Funding Source: Medline
Purpose of review We have examined the evidence from recent human studies examining the role of apolipoprotein AN in triglyceride-rich lipoprotein metabolism and cardiovascular disease risk. Special emphasis was placed on the evidence emerging from the association between genetic variability at the apolipoprotein A5 locus, lipid phenotypes and disease outcomes. Moreover, we address recent reports evaluating apolipoprotein A5 gene-environment interactions in relation to cardiovascular disease and its common risk factors. Recent findings Several genetic association studies have continued to strengthen the position of APOA5 as a major gene that is involved in triglyceride metabolism and modulated by dietary factors and pharmacological therapies. Moreover, genetic variants at this locus have been significantly associated with both coronary disease and stroke risks. Summary Apolipoprotein A-V has an important role in lipid metabolism, specifically for triglyceride-rich lipoproteins. However, its mechanism of action is still poorly understood. Clinical significance at present comes largely from genetic studies showing a consistent association with plasma triglyceride concentrations. Moreover, the effects of common genetic variants on triglyceride concentrations and disease risk are further modulated by other factors such as diet, pharmacological interventions and BMI. Therefore, these genetic variants could be potentially used to predict cardiovascular disease risk and individualize therapeutic options to decrease cardiovascular disease risk.
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