期刊
CURRENT OPINION IN INFECTIOUS DISEASES
卷 26, 期 3, 页码 270-276出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QCO.0b013e32835fb920
关键词
aspergillosis; candidiasis; fungal infections; pathogenesis
资金
- Ministerio de Economia y Competitividad, Instituto de Salud Carlos III
- European Development Regional Fund 'A way to achieve Europe' ERDF
- Spanish Network for the Research in Infectious Diseases [REIPI RD12/0015]
- Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (Madrid) [FIS10/01318]
- Juan de la Cierva research grant from the Instituto de Salud Carlos III, Madrid, Spain
- Spanish Network Research of Infectious Disease (REIPI) [RD06/0008/0022]
Purpose of review Invasive fungal infection (IFI) is increasingly being recognized as a significant cause of morbidity and mortality in immunosuppressed patients. This review focuses on the latest literature reports concerning the pathogenesis of IFI in this population. Recent findings New virulence factors of Candida and Aspergillus have recently been identified. The past few months have brought significant advances in our understanding of how the immune system acts against fungal infection, especially with regard to the role of mucosa in the innate immune system, the arsenal of innate immune recognition receptors and the pathways connecting innate and adaptive immunity. Summary Knowledge of fungal pathogenesis and host immune response can help to optimize the management of fungal infections. Greater understanding of these processes may aid physicians in developing better prophylactic measures and antifungal or immunomodulatory therapies.
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