期刊
CURRENT OPINION IN INFECTIOUS DISEASES
卷 21, 期 3, 页码 279-286出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QCO.0b013e3282f88b5d
关键词
C-type lectins; innate immune responses; mycobacteria; NOD-like receptors; toll-like receptors
资金
- National Research Foundation of Korea [전06A1115, R13-2007-020-01001-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Purpose of review The recent discovery of novel classes of receptors, including toll-like receptors and nucleotide-binding oligomerization domain (NOD)-like receptors is challenging the crucial role of the innate immune system in the recognition of Mycobacterium tuberculosis. The present review is to focus on the roles and mechanisms of specific pattern-recognition receptor-microbial interaction for the host defense against mycobacterial infections. Recent findings Toll-like receptors, key players in innate immunity, are now known to be important for the initiation and coordination of host responses to Mycobacterium tuberculosis. The interaction of Mycobacterium tuberculosis with toll-like receptors triggers intracellular signaling cascades that culminate in a proinflammatory response, but can also trigger signals that dampen the innate immune response. Other membrane-bound pattern-recognition receptors, including the mannose receptor, DC-SIGN, and Dectin-1, contribute to the propagation of Mycobacterium tuberculosis inflammatory signals, and Nod-like receptors (cytosolic pattern-recognition receptors) also act in modulating host recognition of Mycobacterium tuberculosis. Interactions between toll-like receptors and other pattern-recognition receptors are also evident in responses to Mycobacterium tuberculosis, as are possible mechanisms for coordination of innate and adaptive immunity. Summary The complexity of Mycobacterium tuberculosis-pattern-recognition receptor interactions and their effects on host cell responses suggest key roles for innate immunity in controlling Mycobacterium tuberculosis, and the possibility of developing novel therapeutics for tuberculosis that target Mycobacterium tuberculosis-regulated innate immunity pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据