期刊
CURRENT OPINION IN IMMUNOLOGY
卷 31, 期 -, 页码 87-96出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.10.004
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资金
- NIH from the National Institute of Arthritis and Musculoskeletal and Skin Diseases [P50-AR04522, R01-AR047988, R01-AR049449]
- National Institute of Allergy and Infectious Diseases [R01-AI079621]
- Alliance for Lupus Research
- National Human Genome Research Institute [R01-HG006693]
- NIH [R01-AR043814, R21-AR065626]
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder. Considerable progress has been made to delineate the genetic control of this complex disorder. In this review, selected aspects of human and mouse genetics related to SLE are reviewed with emphasis on genes that contribute to both innate and adaptive immunity and to genes that contribute directly to susceptibility to end organ damage. It is concluded that the interactions among these two major pathways will provide further insight into the pathogenesis of SLE. An interactive model of the two major pathways is proposed without emphasis on the importance of breaking tolerance to autoantigens.
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