期刊
CURRENT OPINION IN IMMUNOLOGY
卷 29, 期 -, 页码 137-142出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.06.003
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资金
- NIAID, National Institutes of Health [AI001171-01]
- Japan Society for the Promotion of Science
CD4 T cells are critical for control of Mycobacterium tuberculosis (Mtb) infection and represent the best hope for vaccine-elicited protection. However, little is understood about the properties of Mtb-specific CD4 T cells that mediate control, and the lack of correlates of protection present a significant barrier to the rational development of new vaccination and therapeutic strategies which are sorely needed. Here we discuss the features of protective CD4 T cells including recent evidence for IFN-gamma dependent and independent mechanisms of protection, poor protection by terminally differentiated cells and the importance of T cell migratory capacity for the control of Mtb infection.
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