期刊
CURRENT OPINION IN IMMUNOLOGY
卷 26, 期 -, 页码 56-62出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.10.013
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类别
资金
- Institut Pasteur
- INSERM
- Fondation pour la Recherche Medicale
- European Research Council
A decade ago the first movies depicting T cell behavior in vivo with the help of two-photon microscopy were generated. These initial experiments revealed that T cells migrate rapidly and randomly in secondary lymphoid organs at steady state and profoundly alter their behavior during antigen recognition, establishing both transient and stable contacts with antigen-presenting cells (APCs). Since then, in vivo imaging has continuously improved our understanding of T cell activation. In particular, recent studies uncovered how T cells may be guided in their search for the best APCs. Additionally, the development of more sophisticated fluorescent tools has permitted not only to visualize T cell-APC contacts but also to probe their functional impact on T cell activation. These recent progresses are providing new insights into how T cells sense antigen, collect activation signals during distinct types of interaction and integrate information over successive encounters.
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