期刊
CURRENT OPINION IN IMMUNOLOGY
卷 25, 期 1, 页码 46-52出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2012.12.007
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资金
- Cancer Research UK
- Fondation Bettencourt-Schueller
- ERC
- Ramon y Cajal fellowship from Spanish Ministry of Innovation and Science
- Fundacion Centro Nacional de Investigaciones Cardiovasculares 'Carlos III' (CNIC)
- Spanish Science and Innovation Ministry
- European Research Council (ERG Starting Independent Researcher Grant)
- Cancer Research UK [15689] Funding Source: researchfish
Molecules associated with dead or dying cells can be detected by receptors on macrophages and dendritic cells. Signals from these receptors impact myeloid cell function and play a role in determining whether death is silent or proinflammatory, tolerogenic or immunogenic. Prominent among myeloid receptors detecting dead cells are C-type lectin receptors (CLRs). Signals from these receptors variably induce endocytosis of cell corpses, corpse degradation, retrieval of dead cell-associated antigens and/or modulation of immune responses. The sensing of tissue damage by myeloid CLRs complements detection of pathogens in immunity and represents an ancient response aimed at restoring tissue homeostasis.
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