期刊
CURRENT OPINION IN IMMUNOLOGY
卷 25, 期 4, 页码 504-510出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.07.006
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资金
- NIH/NIAID [R01 AI073939, R21 AI096446-01A1]
- NIH/NIA [R01 AG030227, R01 AG025256, R21 AG042826-01A1]
Immune system function declines with age. Here we review and compare age-associated changes in murine and human B cell pools and humoral immune responses. We summarize changes in B cell generation and homeostasis, as well as notable changes at the subcellular level; then discuss how these changes help to explain alterations in immune responses across the adult lifespan of the animal. In each section we compare and contrast findings in the mouse, arguably the best animal model of the aging immune system, with current understanding of B cell immunity in humans
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