期刊
CURRENT OPINION IN IMMUNOLOGY
卷 25, 期 6, 页码 670-675出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.10.004
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类别
资金
- Institut National de la Sante et de la Recherche Medicale
- Centre National de la Recherche Scientifique
- European Foundation for the study of Diabetes/Novo Nordisk Program in Diabetes Research
- European Foundation for the study of Diabetes/Lilly European Program
- Agence Nationale pour la Recherche
- Juvenile Diabetes Research Foundation
- European Communities Marie Curie Program
- Tondation pour la Recherche Medicale'
Type 1 diabetes is a T cell mediated autoimmune disease where both central and peripheral mechanisms effect T cell tolerance induction. Dendritic cells (DCs) are key regulators of innate and adaptive immune responses. They significantly contribute to central and peripheral T cell tolerance and, following maturation, induce the activation and differentiation of naive T cells into effector and memory cells. DCs are also major actors in inflammation. Given these multiple effects on immune responses, DCs are suspected to contribute to autoimmune diseases. In this review we discuss how some specific features of DC may contribute to type 1 diabetes.
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