期刊
CURRENT OPINION IN IMMUNOLOGY
卷 25, 期 1, 页码 120-125出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2012.12.001
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资金
- NCI NIH HHS [U54 CA148967] Funding Source: Medline
- NIAID NIH HHS [R01 AI083408] Funding Source: Medline
T cells discriminate between peptide-MHC complexes on the surfaces of antigen presenting cells to enact appropriate downstream responses. Great progress has been made over the last 15 years in understanding varied aspects of T cell activation on short timescales (minutes), yet the mechanics and significance of long term T cell receptor signaling (hours or days) remain unclear. Furthermore, there remain some controversies regarding the correlation of the biophysical parameters of ligand-receptor interactions with the scaling of downstream effector functions. Here we review recent studies that emphasize the importance of long-term engagement of antigens to fine-tuning the activation of T cells over the duration of the complete immune response. We discuss how T cells dynamically regulate T cell receptor signaling via antigen crosstalk, competition and consumption to accurately counter antigenic challenges.
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