期刊
CURRENT OPINION IN IMMUNOLOGY
卷 24, 期 1, 页码 41-50出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.12.006
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资金
- National Institutes of Health [RO1GM066025, R01 GM057171]
- National Science Foundation [IOS-0929410]
- Human Frontier Science Program [LT00905/2006-L]
The nucleotide-binding domain /eucine-rich repeat proteins (NLRs) represent the major class of intracellular innate immune receptors in plants and animals. Understanding their functions is a major challenge in immunology. This review highlights recent efforts toward elucidating NLR functions in human and plants. We compare unconventional aspects of NLR proteins across the two kingdoms. We review recent advances describing P-loop independent activation, nuclear-cytoplasmic trafficking, oligonnerization and multimerization requirements for signaling, and for expanded functions beyond pathogen recognition by several NLR proteins.
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