期刊
CURRENT OPINION IN IMMUNOLOGY
卷 24, 期 1, 页码 3-9出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.10.004
关键词
-
类别
资金
- Irvington Institute of the Cancer Research Institute
- National Institutes of Health [AI081747, AI044220, AI064332, AI085581, AI076372, AI083214, DK040561]
Intestinal epithelial cells provide an essential line of defense for Caernohabditis elegans against ingested pathogens. Because nematodes consume microorganisms as their food source, there has presumably been selection pressure to evolve and maintain immune defense mechanisms within the intestinal epithelium. Here we review recent advances that further define the immune signaling network within these cells and suggest mechanisms used by the nematode to monitor for infection. In reviewing studies of pathogenesis that use this simple model system, we hope to illustrate some of the basic principles of epithelial immunity that may also be of relevance in higher order hosts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据